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Fakultät Bio- und Chemieingenieurwesen
HEAD OF LABORATORY

Prof. Dr. Gabriele Sadowski

THERMODYNAMICs FOR FORMULATION DEVELOPMENT

Small molecule pharmaceutics and complex liquid systems

CURRENT

Projects

Phase Behavior of Drug Delivery Systems as Function of pH and Salt Concentration

03/01/2022 - 02/28/2025

The bioavailability of an active pharmaceutical ingredient (API) is often limited by its poor water solubility, which is strongly influenced by pH and the presence of salts. This project develops an adequate model to predict the phase behavior of APIs in water and in (lipid-based) drug delivery systems.

Effect of surfactants on the solubility of pharmaceutical ingredients

05/01/2022 - 04/30/2025

Surfactants are used extensively in industrial and pharmaceutical applications, exploiting their effect on the aqueous solubility of hydrophobic compounds. This project aims at developing an aggregation model to be combined PC-SAFT allowing for predicting the formation of surfactant aggregates and their influence on the solubility of pharmaceutical ingredients.

Liquid-Liquid Equilibria in Aqueous Oil/Surfactant Solutions

09/15/2022 - 09/14/2025

Oil in water emulsions can effectively be used as delivery systems for poorly water soluble drugs. These emulsions are stabilized by surfactants. This project develops a suitable modeling approach for those systems utilizing an aggregation model and PC-SAFT. This will serve as a predictive method capable of describing the complex liquid-liquid phase equilibria in aqueous oil/surfactant solutions.

Influence of coating materials on ASD stability

01/02/2024 - 12/31/2026

Many active pharmaceutical ingredients (APIs) suffer from low aqueous solubility, limiting their bioavailability. Bioavailability can be improved by dissolving the API in a polymer, yielding so-called amorphous solid dispersions (ASDs). This project aims at investigating the influence of coating materials, temperature and relative humidity (RH) on the stability of coated ASDs during storage.

Using Polymer Salts as Excipients in Amorphous Solid Dispersions

07/01/2024 - 06/30/2026

The bioavailability of newly developed active pharmaceutical ingredients (API) is often limited by their low aqueous solubility. The bioavailability of an API can be improved by using amorphous solid dispersions (ASD), which consist of a polymer matrix and the dissolved API. High API drug loads may decrease the pill burden but can lead to an amorphous-amorphous phase separation or crystallization, which ultimately results in a vastly reduced release of API. In this project, the phase behavior and release behavior of ASDs using polymer salts as matrix formers will be investigated in close cooperation with the group of Lynne Taylor from Purdue University.

PUBLICATIONS

Sadowski