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Fakultät Bio- und Chemieingenieurwesen
PhD candidate

M. Sc. Luca Grieser

Project Grieser

07/01/2024 - 06/30/2026

The bioavailability of newly developed active pharmaceutical ingredients (API) is often limited by their low aqueous solubility. The bioavailability of an API can be improved by using amorphous solid dispersions (ASD), which consist of a polymer matrix and the dissolved API. High API drug loads may decrease the pill burden but can lead to an amorphous-amorphous phase separation or crystallization, which ultimately results in a vastly reduced release of API. In this project, the phase behavior and release behavior of ASDs using polymer salts as matrix formers will be investigated in close cooperation with the group of Lynne Taylor from Purdue University.