M. Sc. Lennart Hellfajer
Thermodynamics of self-emulsifying systems
Lipid-based formulations have emerged as promising drug delivery systems to enhance the bioavailability of poorly water-soluble drugs. Upon oral administration, these drug delivery systems spontaneously form emulsions in the gastrointestinal tract, stabilized by surfactants. This project aims to extend existing modelling approaches for surfactant systems, combining a model for the formation of mixed aggregates with PC-SAFT, to enable the prediction of drug solubilization in self-emulsifying drug-delivery systems. This project is funded by RESOLV.




