Influence of High Pressure and of Solvent on a Michael Addition

The thermodynamic variable pressure is an important influencing factor for chemical reactions. Even though liquid phases
are generally assumed to be incompressible, pressure can have a strong influence on reaction kinetics and could therefore
be used to optimize production processes. In this work, the pressure effects on reaction kinetics and reaction equilibrium
of a Michael addition were investigated. An activity-based kinetic modeling was used to predict the effect of pressure and
of solvent on reaction kinetics and reaction equilibrium using PC-SAFT, which allows predicting molecular interactions as
function of pressure and of reaction solvent. Prediction results were in good agreement with experimental data for different
reaction solvents for the first time even at pressures in the kilo bar range.