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Thermodynamic modeling of aqueous surfactant solutions.
- Research Highlights

The low solubility of active pharmaceutical ingredients (APIs) in aqueous solutions is a persisting challenge in drug development and design. Surfactants can be used to encounter this challenge. Once the surfactant concentration exceeds the Critical Micelle Concentration (CMC), the formed aggregates serve as vehicles for the hydrophobic APIs increasing their overall solubility. As a first step towards modeling and understanding aqueous surfactant systems, we present a newly-developed and generic thermodynamic framework. Such a thermodynamic framework provides a valuable tool for tailoring surfactants for solubilizing for target APIs.
- ScientificHighlights_2024_MR.pdf PDF (277 KB)