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Fakultät Bio- und Chemieingenieurwesen

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SCIENTIFIC HIGHLIGHTS 2020

Predicting Protein-Protein Interactions using the ePC-SAFT Equation Of State

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  • Research Highlights
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An efficient formulation design based on thermodynamic modeling

Thermodynamic models are increasingly recognized as essential part in pharmaceutical formulation development of
“small-molecule” drugs. However, modeling of highly complex (bio-)pharmaceuticals (e.g., monoclonal antibodies) remains
a challenging task. Within this work, we developed a modeling approach to access protein-protein and protein-excipient
interactions for pharmaceutical proteins in the presence of different excipients using the ePC-SAFT equation of state. This
approach gives access to protein phase behavior in these complex solutions and allows to gain a mechanistic understanding
on the complex interactions involved enabling an optimized formulation development.