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Predicting Protein-Protein Interactions using the ePC-SAFT Equation Of State
- Research Highlights
Thermodynamic models are increasingly recognized as essential part in pharmaceutical formulation development of
“small-molecule” drugs. However, modeling of highly complex (bio-)pharmaceuticals (e.g., monoclonal antibodies) remains
a challenging task. Within this work, we developed a modeling approach to access protein-protein and protein-excipient
interactions for pharmaceutical proteins in the presence of different excipients using the ePC-SAFT equation of state. This
approach gives access to protein phase behavior in these complex solutions and allows to gain a mechanistic understanding
on the complex interactions involved enabling an optimized formulation development.
- ScientificHighlights_2020_MS.pdf PDF (990 KB)